Ageing and the border between health and disease.

نویسندگان

  • William MacNee
  • Roberto A Rabinovich
  • Gourab Choudhury
چکیده

Ageing is associated with a progressive degeneration of the tissues, which has a negative impact on the structure and function of vital organs and is among the most important known risk factors for most chronic diseases. Since the proportion of the world's population aged >60 years will double in the next four decades, this will be accompanied by an increased incidence of chronic age-related diseases that will place a huge burden on healthcare resources. There is increasing evidence that many chronic inflammatory diseases represent an acceleration of the ageing process. Chronic pulmonary diseases represents an important component of the increasingly prevalent multiple chronic debilitating diseases, which are a major cause of morbidity and mortality, particularly in the elderly. The lungs age and it has been suggested that chronic obstructive pulmonary disease (COPD) is a condition of accelerated lung ageing and that ageing may provide a mechanistic link between COPD and many of its extrapulmonary effects and comorbidities. In this article we will describe the physiological changes and mechanisms of ageing, with particular focus on the pulmonary effects of ageing and how these may be relevant to the development of COPD and its major extrapulmonary manifestations.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Future of Ageing and Its Health Care Costs: A Warning for Health System

This article is focused on ageing and the rapid ageing population growth, from future health care costs prospectus. It reviews ageing population statistics in several courtiers as well as Iran, to illustrate the significance of the ageing population growth in the next decades. Nevertheless, the health care costs for elderly people are described and the considerable differences between health ca...

متن کامل

The Relationship Between Personality Traits of Older Adults and Elder Abuse

Objectives This study aims to investigate the relationship between the big-five personality traits (extroversion, neuroticism, agreeableness, conscientiousness, and openness to experience) and elder abuse. Methods & Materials In this cross-sectional study, 304 older adults (60 years old and older) were selected by convenience sampling method based on the inclusion criteria among older adults w...

متن کامل

Successful Ageing in the Dimensions of Life Satisfaction and Perception of Ageing in the Iranian Elderly Adults Referring to the Health Center in the West of Tehran, Iran

Background & Aims: Achieving the goals of successful ageing is considered to be an effective strategy for the promotion of health in the elderly. The concept of healthy and successful ageing encompasses significant components, including life satisfaction, positive perception of the changes in old age, longevity, lack of disability, and independence in life. The present study aimed to assess suc...

متن کامل

Physical Activity in the Elderly with Fall Experience Over the Past Year: Results from Amirkola Health and Ageing Project

Background and purpose: Nowadays, immobility is known to be the fourth risk factor for mortality. The aim of the present study was to investigate the relationship between fall experience over the previous year and levels of physical activity in the elderly. Materials and Methods: The study was performed with 1616 participants of 60≤ years. The relationship between physical activities in the el...

متن کامل

Predictors of Healthcare Expenditure: Aging, Disability or Development?

Objective: Studies show that almost every country across the world will experience a remarkable increase in their healthcare costs and ageing population by 2030. Also, people with disabilities are more likely to impose considerable healthcare costs on families and governments than their counterparts. On the other hand, socioeconomic status of countries can be an important factor to predict heal...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The European respiratory journal

دوره 44 5  شماره 

صفحات  -

تاریخ انتشار 2014